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組織工程 Tissue Engineering-生物名詞

放大字體  縮小字體 發(fā)布日期:2005-05-13

結合細胞遺傳工程和化學工程以創(chuàng)造器官和組織如:皮膚、骨頭、心臟瓣膜和軟骨關節(jié)的技術。例如,骨生長因子或干細胞可以在孔狀物質中生長,產生頜或四肢。在另一個例子中,可以制造新的微小器官;從豬的身上純化出產生胰島素的胰島細胞裝入用特殊膜做成的膠囊然后送到糖尿病患者的腹部。這些細胞受到合成膜的保護而不會被免疫系統拒絕,但同時又可以在生理狀態(tài)下釋放胰島素。同樣肝細胞可以裝入膠囊產生小的肝。最后,取代損壞軟骨關節(jié)或可導入虛弱組織壁的合成物質也正在開發(fā)中。


Technology combining genetic engineering of cells with chemical engineering to create artificial organs and tissues such as skin, bone, heart valves, and cartilage for joints. For example, bone growth factors or stem cells can be grown within a porous material (cut to shape) to create new jaws or limbs. In a second example, new miniorgans can be created; Islet cells that produce insulin have been purified from pigs and encapsulated in a special membrane before introduction into the abdomen of diabetic patients. These cells are protected from immune rejection by the synthetic membrane, but can release insulin in a physiological manner. Similarly, liver cells can be encapsulated to generate mini-livers. Finally, synthetic materials that can replace damaged cartilage in joints or that can be introduced into weakened tissue walls are also under development.

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